Skin-smoothing treatment with retinol & peptides The Clinical 1% Retinol Treatment by Paula's Choice contains highly effective retinol that is known for its anti-aging properties. It smooths the skin, stimulates cell renewal and fades brown spots. In combination with antioxidants and peptides, the treatment has the ability to improves the skin's overall appearance. A fast-absorbing cream that does not cause a greasy feel. Application: Apply a pea-sized amount after cleansing and toning, and then follow with your serum and/or nighttime moisturiser. Avoid the lips, direct contact with the eyes, and corners of the eyes. You may apply up to the orbital bone of the eye area. When first using the Clinical 1% Retinol, start with no more than 3 evenings per week, then gradually increase frequency to every other night and, finally, every evening as tolerated.